PT-141 10mg

PT-141, also known as Bremelanotide, is a cyclic seven-amino acid synthetic peptide and a metabolic byproduct of Melanotan II. It acts as an agonist at melanocortin receptors MC3R and MC4R, with research primarily focused on its potential influence over central nervous system activity and reproductive function.

Chemical Makeup Molecular Formula: C50H68N14O10 | Molecular Weight: 1025.18 g/mol | Also known as: Bremelanotide

Research Highlights

• Initial Studies — Early murine research suggested PT-141 may selectively stimulate appetitive sexual behavior in female models without impacting general motor function, pointing to a targeted effect on central melanocortin receptor activity.
• Arousal & Tissue Response — Research suggests MC4R activation by PT-141 may upregulate nitric oxide production in penile tissue, potentially increasing cavernosal pressure through neuronal NO release — an effect that appeared negated when pudendal nerves were removed or NO synthase was inhibited.
• CNS Mechanisms — Studies indicate PT-141 may activate the medial preoptic area (mPOA) and surrounding hypothalamic and limbic regions associated with sexual behavior, possibly via dopamine terminal activation. Effects were observed following both peripheral and direct CNS introduction.
• Brain Processing — A randomized, double-blind, placebo-controlled trial found MC4R agonism may elevate sexual desire for up to 24 hours, amplify cerebellar and motor area activity, and boost functional connectivity between the amygdala and insula when subjects were exposed to erotic stimuli.

Available for research and laboratory purposes only.