ARA - 290 10mg

ARA-290 (also called cibinetide) is a synthetic 11-amino-acid peptide derived from erythropoietin (EPO) designed to reduce inflammation and repair damaged nerves without increasing red blood cell production.

Chemical and Molecular Data:

Molecular Formula: C₅₁H₈₄N₁₆O₂₁

Molecular Weight / Molar Mass: ~1,257.32 g/mol

Formal Name: 5-oxo-L-prolyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-α-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-serine (acetate form available)

Research Highlights

Mechanism of Action: It selectively binds to the innate repair receptor (IRR)—composed of the EPOR/βcR heterodimer—to trigger anti-inflammatory and anti-apoptotic signaling pathways.

No Hematopoietic Effects: Unlike full-length EPO, it does not increase hemoglobin, hematocrit, or red blood cell counts, avoiding cardiovascular or thickening risks of blood.

Small Fiber Neuropathy (SFN): Clinical studies show promise in reducing neuropathic pain and improving corneal nerve fiber density in patients with sarcoidosis-associated small fiber neuropathy and type 2 diabetes.

Preclinical models suggest it dampens activated spinal microglia and astrocytes, alleviating mechanical allodynia and supporting axon regrowth.

Regulatory Status: Despite positive Phase II proof-of-concept trials, it remains an investigational compound and lacks formal FDA approval.

Available for research and laboratory purposes only.