5-Amino-1MQ 50mg

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) rather than a peptide. By inhibiting NNMT, research has examined its potential to shift nicotinamide toward NAD+ salvage pathways and to influence adipocyte metabolism and cellular energy regulation.

Chemical Makeup Molecular Formula: C10H11N2+ (commonly supplied as the iodide salt, C10H11IN2) | Molecular Weight: 159.21 g/mol (cation) | Also known as: 5-amino-1-methylquinolinium

Research Highlights

• NNMT Inhibition — Research describes 5-Amino-1MQ as a cell-permeable inhibitor of nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide and diverts it from NAD+ synthesis.
• Adipocyte Metabolism — Studies in murine adipocyte models suggest NNMT inhibition may reduce fat cell size and lipogenic activity without an apparent effect on food intake.
• NAD+ and SAM Levels — Research indicates inhibition may raise intracellular NAD+ and S-adenosylmethionine levels in treated tissue.
• Diet-Induced Obesity Models — In murine studies on high-fat diets, treatment was associated with reduced body weight and white adipose tissue mass relative to controls.
• Muscle Tissue — Preliminary research has examined NNMT inhibition in models of age-related muscle decline, where NNMT expression is reportedly elevated.

Available for research and laboratory purposes only.