FOXO4-DRI 10mg

FOXO4-DRI is a synthetic D-retro-inverso peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53. Built entirely from D-amino acids in reversed sequence order, the retro-inverso design is intended to resist enzymatic degradation while preserving the binding surface of the native sequence. Research has focused on senescent cell biology.

Chemical Makeup 45-amino-acid D-retro-inverso peptide | Approximate Molecular Weight: 5.2 kDa | Also known as: FOXO4-DRI, FOXO4 D-Retro-Inverso

Research Highlights

• Senescent Cell Targeting — Research suggests FOXO4-DRI may selectively induce apoptosis in senescent cells by releasing p53 from FOXO4 sequestration in the nucleus, while leaving proliferating cells largely unaffected.
• Aged Tissue Models — In naturally aged murine models, the peptide appeared to restore markers of fitness, fur density, and renal function relative to untreated controls.
• Chemotoxicity Models — Studies in doxorubicin-treated murine models reported reduced markers of senescence-associated tissue damage following exposure.
• Renal Markers — Research reported reductions in blood urea nitrogen in treated aged models, suggesting possible influence on kidney function.
• Mechanism — Activity is attributed to interference with the FOXO4-p53 protein-protein interaction rather than general cytotoxicity, which is the basis for the selectivity reported in published work.

Available for research and laboratory purposes only.