Kisspeptin 10mg

Kisspeptin-10 is a naturally occurring 10-amino acid peptide fragment derived from the KISS1 gene product, produced through successive cleavage of the original 145-amino acid polypeptide. Originally identified as a metastasis suppressor for melanomas and breast carcinomas, research has since expanded to explore its role as a ligand for the G-protein coupled receptor GPR54 (KISS1R) — a key regulator of the hypothalamic-pituitary-gonadal axis. Studies suggest it may stimulate GnRH and gonadotropin release, with additional research pointing to roles in emotional modulation, appetite regulation, and neuroprotection.

Chemical Makeup Molecular Formula: C63H83N17O14 | Molecular Weight: 1302.4 g/mol | Also known as: Kisspeptin 45-54

Research Highlights

• Reproductive Hormone Regulation — A comprehensive 2017 literature review supported the hypothesis that the KISS1/GPR54 system may regulate gonadotropin hormone release, with studies in animal models linking abnormalities in this system to conditions including hypogonadotropic hypogonadism and PCOS.
• Delayed Hormonal Development — In models of stunted hormonal development, Kisspeptin-10 appeared to increase LH levels in approximately 47% of subjects, with an additional 6% showing intermediate responses, suggesting potential in reproductive hormone stimulation research.
• Reproductive Hormone Release — Studies in male models found increased FSH and LH following peptide exposure; in female models, elevated FSH and LH were observed specifically during the preovulatory phase.
• Emotional Modulation — Neuroimaging and psychometric analysis following Kisspeptin-10 exposure indicated enhanced limbic brain activity and increased responsiveness to sexual and bonding stimuli.
• Food Intake & Appetite — Murine studies suggest Kisspeptin-10 may reduce meal frequency and total meal time in fasted models during the first 12 hours post-exposure. Research also indicates the peptide may elevate NPY gene expression while suppressing BDNF and reducing serotonin and dopamine concentrations in hypothalamic cells — collectively suggesting an influence on hunger signaling.
• Neuroprotection — Research indicates Kisspeptin-10 may bind to amyloid-beta (Aβ) extracellularly, potentially reducing its neurotoxic effects. Studies in cholinergic neurons also suggest the peptide may lessen apoptosis and mitochondrial damage induced by both wild-type and E46K mutant forms of alpha-synuclein, independent of GPR54 receptor activation.

Available for research and laboratory purposes only.