Dihexa 10mg

Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a synthetic angiotensin IV analog engineered for high metabolic stability. Research has focused on its potential as a positive modulator of hepatocyte growth factor (HGF) and its receptor c-Met, with particular attention to synapse formation and cognitive models.

Chemical Makeup Molecular Formula: C31H51N5O6 | Molecular Weight: 613.78 g/mol | Also known as: PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide

Research Highlights

• HGF/c-Met Potentiation — Research suggests Dihexa may act as an allosteric potentiator of hepatocyte growth factor, enhancing c-Met receptor dimerization and downstream signaling at picomolar concentrations.
• Synaptogenesis — Studies in cultured hippocampal neurons found Dihexa exposure was associated with increased spinogenesis and the formation of functional synapses.
• Cognitive Models — In scopolamine-induced cognitive deficit murine models, Dihexa appeared to restore performance in spatial learning and memory tasks.
• Metabolic Stability — Structural modification of the parent angiotensin IV sequence reportedly confers substantially greater resistance to enzymatic degradation.
• Neurotrophic Potential — Research has explored the compound in models of neurodegeneration where HGF/c-Met signaling is implicated in neuronal repair.

Available for research and laboratory purposes only.