Thymosin Alpha-1 10mg

Thymosin Alpha-1 (also known as TA1, Tα1, or Thymalfasin) is a naturally occurring 28-amino acid polypeptide fragment derived from Prothymosin Alpha, found in Thymosin Fraction 5 — a crude extract of the thymus gland. Widely studied for its immunomodulatory properties, research suggests it may stimulate T-cell differentiation, enhance natural killer cell activity, increase cytokine production, and potentially restore compromised immune function across a range of conditions.

Chemical Makeup Molecular Formula: C129H215N33O55 | Molecular Weight: 3108.31 g/mol | Also known as: TA1, Tα1, Thymalfasin

Research Highlights

• Immune Modulation — Studies suggest Thymosin Alpha-1 may increase MHC class I expression, elevate cytokine production, enhance natural killer cell activity, and upregulate high-affinity IL-2 receptors — potentially supporting more vigorous T lymphocyte activation and proliferation.
• Hepatitis — Clinical trials in subjects with Hepatitis B found twice-weekly Thymosin Alpha-1 exposure appeared to increase virological response rates by 40.6%. In Hepatitis C subjects, results appeared improved when combined with interferon alpha compounds, potentially via TLR-2 and TLR-9 modulation on dendritic cells.
• Sepsis — A 2015 meta-analysis of 12 controlled trials found a reported significant decline in mortality rates following Thymosin Alpha-1 introduction in sepsis subjects, with subsequent reviews supporting its potential to alleviate sepsis-associated immunosuppression.
• HIV Research — A randomized Phase II trial in 20 subjects on HAART found Thymosin Alpha-1 appeared to increase sjTREC levels after 12 weeks — potentially indicating modest improvements in thymic output and immune reconstitution, though overall T-cell counts remained largely unchanged.
• Cancer Research — In liver carcinoma murine models, Thymosin Alpha-1 appeared to increase ROS in leuko-monocytes while decreasing it in HepG2 cancer cells, potentially delaying the cancer cell cycle via Akt pathway dephosphorylation. Studies in lung cancer cells (A549) suggest the peptide may exhibit anti-proliferative and anti-migratory action while enhancing antioxidant enzyme activity including catalase, SOD, and glutathione peroxidase.

Available for research and laboratory purposes only.