DSIP 5m

DSIP (Delta Sleep-Inducing Peptide)

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nine-amino acid neuropeptide first isolated from the central nervous system of electrically-induced sleep models between 1963 and 1977. Originally studied for its sleep-inducing properties, research has since expanded to explore its potential roles in stress modulation, endocrine regulation, pain mitigation, withdrawal management, and longevity. DSIP is hypothesized to act via multiple receptor pathways including GABA, NMDA, opioid, and alpha-1 adrenergic receptors.

Chemical Makeup Molecular Formula: C35H48N10O15 | Molecular Weight: 848.82 g/mol | Also known as: DSIP nonapeptide, Emideltide

Research Highlights

• Sleep Cycles — In feline models, DSIP appeared to significantly increase total sleep and slow wave sleep (SWS) within the first hour of exposure, with effects sustained for up to 7 hours. A clinical study reported a 59% increase in sleep within two hours of initiation, alongside improved sleep efficiency and shortened sleep onset.
• Endocrine Regulation — Murine studies found DSIP may significantly elevate luteinizing hormone (LH) levels within 30 minutes without impacting FSH. Additional research suggests DSIP may stimulate growth hormone secretion via dopaminergic mechanisms, potentially linking it to GH release during slow-wave sleep phases.
• Stress Response — Studies examining substance P, beta-endorphin, and corticosterone levels in stressed murine models suggest DSIP may modulate the stress response, with observed decreases in corticosterone shortly after exposure and fluctuations in beta-endorphin consistent with opioidergic stress adaptation.
• Longevity — A murine longevity study found DSIP appeared to improve lifespan by 24%, reduce chromosomal aberrations in bone marrow by 23%, and decrease malignancy occurrence by 2.5-fold compared to controls.
• Antioxidant Properties — Research suggests DSIP may inhibit lipid peroxidation by reducing malonic dialdehyde levels and stimulating endogenous antioxidant enzyme systems including superoxide dismutase, catalase, and ceruloplasmin — particularly during later stages of aging.

Available for research and laboratory purposes only.