TB-500 10mg

TB-500 is a synthetic 43-amino acid peptide analog of the naturally occurring Thymosin Beta-4 protein, found in thymus cells and encoded by the TMSB4X gene. Its primary mechanism centers on actin sequestration — binding to globular actin (G-actin) to modulate cytoskeletal structure — which researchers believe underlies its potential in cell migration, wound healing, angiogenesis, and tissue regeneration. TB-500 has been studied across a broad range of applications including acute and chronic wound healing, cardiac repair, hair growth, corneal healing, and anti-inflammatory action.

Chemical Makeup Molecular Formula: C212H350N56O78S | Molecular Weight: 4963 g/mol | Also known as: Thymosin Beta-4

Research Highlights

• Acute Wound Healing — A 1999 murine study found TB-500 produced a 41% increase in re-epithelialization at day 4 and at least 11% greater wound contraction by day 7, with researchers describing it as "a potent wound healing factor with multiple activities."
• Chronic Wounds — Studies across diabetic, aged, and steroid-influenced animal models found TB-500 accelerated wound healing regardless of pre-existing conditions, with Phase 2 clinical trials suggesting healing acceleration of up to one month in pressure and stasis ulcer models.
• Anti-Inflammatory Action — Research suggests TB-500 may upregulate miR-146a, potentially suppressing inflammatory cytokine pathways including IRAK1 and TRAF6, contributing to its broader anti-inflammatory profile.
• Cardiac Repair — Studies indicate TB-500 may enhance myocardial cell resilience under hypoxic conditions, promote angiogenesis in cardiac tissue, activate ILK and Akt pathways for early cardiomyocyte survival, and potentially facilitate cardiac fibroblast differentiation into cardiomyocyte-like cells.
• Angiogenesis — Research in HUVEC and murine ischemia models suggests TB-500 may promote blood vessel formation via Notch and NF-κB pathway modulation, with elevated expression of VEGFA, Ang2, and other angiogenic markers observed.
• Hair Growth — A 2003 murine study found TB-500 increased hair shaft and follicle count via histological examination, with elevated mRNA and protein expression levels confirmed by PCR and western blotting.
• Corneal Healing — Studies suggest TB-500 may reduce neutrophil infiltration, modulate NF-κB inflammatory signaling, and inhibit apoptosis in corneal epithelial cells via caspase inhibition and Akt activation.

Available for research and laboratory purposes only.