Epithalon

Epithalon (also known as AEDG peptide, Epitalon, or Epithalone) is a synthetic tetrapeptide composed of amino acids Ala-Glu-Asp-Gly, derived from Epithalamin — a naturally occurring peptide of the pineal gland and eye retina. Research has focused on its potential roles in longevity, cellular regeneration, antioxidant activity, sleep regulation, and retinal function.

Chemical Makeup Molecular Formula: C14H22N4O9 | Molecular Weight: 390.34 g/mol | Also known as: Epitalon, Epithalone

Research Highlights

• Longevity — Studies suggest Epithalon may modulate gene expression by interacting with histones, potentially upregulating neuronal differentiation markers by 1.6–1.8x and influencing chromatin dynamics in stem cells.
• Oxidative Stress — Research indicates the peptide may reduce intracellular ROS levels in aged oocytes, preserve spindle integrity, support mitochondrial function, and reduce DNA damage and apoptosis.
• Anti-Aging — Epithalon may inhibit MMP-9 synthesis, suppress caspase-3-dependent apoptosis, and enhance cellular proliferation markers Ki-67 and CD98hc — all of which typically decline with age.
• Telomere Extension — In fetal fibroblast studies, Epithalon appeared to stimulate telomere elongation and enable approximately 10 additional cell divisions beyond the normal Hayflick limit.
• Melatonin & Sleep — In aging primate models, the peptide appeared to restore melatonin levels to normal ranges by stimulating pineal gland-like activity.
• Retinal Health — Clinical studies suggest Epithalon may elevate bioelectric activity in retinal cells and reverse age-related degeneration, with positive outcomes reported in 90% of geriatric subjects.
• Geroprotective Effects — A 6–8 year study in 266 elderly subjects found Epithalon may support cardiovascular, immune, endocrine, and nervous system function, with an approximate 1.8-fold reduction in mortality rates.
• Anti-Mutagenic — Murine studies suggest Epithalon may reduce chromosomal aberrations, particularly in models with accelerated aging.

Available for research and laboratory purposes only.